SMS scnews item created by Eduardo Altmann at Thu 16 Aug 2018 1635
Type: Seminar
Modified: Tue 21 Aug 2018 1318
Distribution: World
Expiry: 13 Sep 2018
Calendar1: 29 Aug 2018 1300-1400
CalLoc1: AGR Carslaw 829
CalTitle1: Robust Perfect Adaptation in Complex Bionetworks
Auth: ega@dora.maths.usyd.edu.au

Applied Maths Seminar

Robust Perfect Adaptation in Complex Bionetworks

Araujo

Dr. Robyn Araujo (Queensland Univ. of Tech.)
Title: Robust Perfect Adaptation in Complex Bionetworks
Abstract: Robustness, and the ability to function and thrive amid changing and unfavourable environments, is a fundamental requirement for all living systems. Moreover, it has been a long-standing mystery how the extraordinarily complex communication networks inside living cells, comprising thousands of different interacting molecules, are able to exhibit such remarkable robustness since complexity is generally associated with fragility. In this talk I will give an overview of our recent research on robustness in cellular signalling networks, with an emphasis on the robust functionality known as Robust Perfect Adaptation (RPA). This work is now published in Nature Communications, and is available here: https://rdcu.be/M46K. This work has suggested a resolution to the complexity-robustness paradox through the discovery that robust adaptive signalling networks must be decomposable into topological basis modules of just two possible types. This newly-discovered modularisation of complex bionetworks has important implications for evolutionary biology, embryology and development, cancer research and drug development.
Applied Maths Seminars


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