SMS scnews item created by Andrew Mathas at Thu 23 May 2013 1336
Expiry: 31 May 2013
Calendar1: 31 May 2013 1400-1500
CalLoc1: AGR Carslaw 829
CalTitle1: AGR Seminar: Secondary analysis of nested case-control data: methods and practical implications
Auth: email@example.com (assumed)
Secondary analysis of nested case-control data: methods and practical implications
Dr Agus Salim (Department of Mathematics and Statistics, La Trobe University)
La Trobe University
Many epidemiological studies use a nested case-control (NCC) design to reduce cost while maintaining study power. However, since the sampling was conditional on the primary outcome and matching variables, re-using nested case-control data to analyse a secondary outcome is not straightforward. Recently, several authors have proposed methods that can be used to analyse secondary outcome. I will discuss the currently available methods and further propose a maximum likelihood method that where the likelihood contribution is derived by respecting the original sampling procedure with respect to the primary outcome. Using simulation study and real dataset from a Swedish cohort, we compare the performance of the different methods and assess practical implications of re-using nested case-control data in terms of statistical efficiency.
Dr Andriy Olenko
If you would like to attend this seminar in our access grid room then please check to see if the grid is already booked at this time and send an email to firstname.lastname@example.org to let the CSOs know that you would like to attend.