Sanjay Chawla School of Information Technologies, University of Sydney Protein Secondary Structure Prediction with Conditional Random Fields Wednesday 6th June 14:05-14:55pm, Eastern Avenue Lecture Theatre. Conditional Random Fields (CRFs) are a generalization of logistic regression for classifying sequential data. In this talk we will demonstrate the use of CRFs to predict the secondary structure of integral membrane proteins. Compared to other discriminative classifiers, CRFs overcome the label-bias problem and also allow for a seamless integration of biological domain knowledge into the model. This is joint work with Lior Lukov and Brett Church.