%PDF-1.4 5 0 obj << /S /GoTo /D (section.1) >> endobj 8 0 obj (Introduction) endobj 9 0 obj << /S /GoTo /D (section.2) >> endobj 12 0 obj (Development of atherosclerotic lesions and the role of HDL) endobj 13 0 obj << /S /GoTo /D (subsection.2.1) >> endobj 16 0 obj (Early stage disease processes) endobj 17 0 obj << /S /GoTo /D (subsection.2.2) >> endobj 20 0 obj (HDL and its role in atherosclerosis) endobj 21 0 obj << /S /GoTo /D (subsection.2.3) >> endobj 24 0 obj (HDL as a therapeutic target) endobj 25 0 obj << /S /GoTo /D (section.3) >> endobj 28 0 obj (Modelling the effect of HDL on the basic inflammatory response ) endobj 29 0 obj << /S /GoTo /D (section.4) >> endobj 32 0 obj (Model Analysis and Results) endobj 33 0 obj << /S /GoTo /D (subsection.4.1) >> endobj 36 0 obj (Cholesterol Efflux) endobj 37 0 obj << /S /GoTo /D (subsection.4.2) >> endobj 40 0 obj (Cholesterol efflux and constant macrophage and foam cell emigration rates) endobj 41 0 obj << /S /GoTo /D (subsection.4.3) >> endobj 44 0 obj (Cholesterol efflux and non-constant macrophage and foam cell emigration rates) endobj 45 0 obj << /S /GoTo /D (subsection.4.4) >> endobj 48 0 obj ( HDL-dependent modLDL influx and macrophage recruitment) endobj 49 0 obj << /S /GoTo /D (section.5) >> endobj 52 0 obj (Implications of the model) endobj 53 0 obj << /S /GoTo /D (subsection.5.1) >> endobj 56 0 obj (HDL stabilises and reduces lesion size via cholesterol efflux and foam cell emigration) endobj 57 0 obj << /S /GoTo /D (subsection.5.2) >> endobj 60 0 obj (HDL's anti-oxidative property reduces internalised lipid content) endobj 61 0 obj << /S /GoTo /D (subsection.5.3) >> endobj 64 0 obj (HDL-enabled macrophage emigration is required to conclusively stabilise active macrophage numbers) endobj 65 0 obj << /S /GoTo /D (subsection.5.4) >> endobj 68 0 obj (Anti-inflammatory properties of HDL help to stabilise macrophage numbers) endobj 69 0 obj << /S /GoTo /D (subsection.5.5) >> endobj 72 0 obj (Implications for treatment strategies and optimal HDL levels) endobj 73 0 obj << /S /GoTo /D (section.6) >> endobj 76 0 obj (Discussion) endobj 77 0 obj << /S /GoTo /D [78 0 R /Fit ] >> endobj 80 0 obj << /Length 2369 /Filter /FlateDecode >> stream xڍXK6ϯQSe!@wuZl瀡87('_7HQnjKU"FwW*54U'hՎqt2K0S3j9+$U1jFJt=}V&RIbyZ.]ToMF^7Ǯ7д̚Dچ^g~ n/wfC_ qƸ^b/ 4Xxis2eL(1D.#}Ldܥ5ۃ ۿGۮ6t-T"2 w5¥i]187[VQ]W?_X810vJmNz%V98dq.?h2voa"C0{8|+OgDI(7sjɵS53bكYCP1^*OLuV.&pl]2# $E-ޝe g6RiG{^?SƏ}vIRC3.sQKrnlYY"ɡ=eQkgih+Uz@凪tշ*']fCywщʳ!U5rV<:I緧~}][$!iUęK(Mԛ99cf r\)$6e,=Ab"˔%UL.G6[ SZZk"n