Nicola Armstrong

School of Mathematics and Statistics
University of Sydney












  • Lazarus J, Mather KA, Armstrong NJ, Song F, Poljak A, Thalamuthu A, Lee T, Kochan NA, Brodaty H, Wright MJ, Ames D, Sachdev PS, Kwok JBJ. DNA Methylation in the Apolipoprotein-A1 Gene is Associated with Episodic Memory Performance in Healthy Older Individuals. Accepted, Journal of Alzheimer's Disease, 2014
  • Mather KA, Armstrong N, Kwok JB, Sachdev PS. The role of epigenetics in cognitive ageing. Accepted, Int J Geriatr Psychiatry, 2014.
  • Ali NA, Wu J, Hochgrafe F, Chan H, Nair R, Ye S, Zhang L, Lyons RJ, Pinese M, Lee HC, Armstrong NJ, Ormandy CJ, Clark SJ, Swarbrick A, Daly RJ. Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signaling networks and conserved oncogenic pathways. Accepted Br Cancer Res, 2014.
  • Warton K, Lin V, Navin T, Armstrong NJ, Kaplan W, Ying K, Gloss B, Mangs H, Nair SS, Hacker NF, Sutherland RL, Clark SJ, Samimi G. Methylation-capture and next-generation sequencing of free circulating DNA from human plasma. BMC Genomics 2014 15(1):476.
  • Ising M, Mather K, Zimmermann P, Bruckl T, Hohne N, Heck A, Schenk L, Rujescu D, Armstrong N, Sachdev P, Reppermund S. Genetic effects on information processing speed are moderated by age - converging results from 3 samples. Genes Brain Behav 2014.
  • Kaufman KL, Mactier S, Armstrong NJ, Mallawaaratchy D, Byrne S, Haydu L, Jakrot V, Thompson JF, Mann GJ, Scolyer RA, Christopherson RI. Surface antigen profiles of leukocytes and melanoma cells in lymph nodes correlate with survival in AJCC stage III metastatic melanoma patients. Accepted Clinical and Experimental Metastasis, 2014.
  • Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, Toro R, Jahanshad N, Schumann G, Franke B, Wright MJ, Martin NG, Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J, Alpert K, Andreasen NC, Andreassen OA, Apostolova LG, Appel K, Armstrong NJ, et al. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav, 2014 Vol 8, No. 2, 153-182.
  • Coupland KG, Mellick GD, Silburn PA, Mather K, Armstrong NJ, Sachdev PS, Brodaty H, Huang Y, Halliday GM, Hallupp M, Kim WS, Dobson-Stone C, Kwok JB. DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin E in vitro. Accepted Mov Disord., 2013.
  • Nair R, Roden DL, Teo WS, McFarland A, Junankar S, Ye S, Nguyen A, Yang J, Nikolic I, Hui M, Morey A, Shah J, Pfefferle A, Usary J, Selinger C, Baker LA, Armstrong N, Cowley M, Naylor MJ, Ormandy CJ, Lakhani SR, Herschkowitz JI, Perou CM, Kaplan W, O'Toole SA, Swarbrick A. c-Myc and Her2 cooperate to drive a stem-like phenotype with poor prognosis in breast cancer. Oncogene 2014; 33(30):3992-4002.
  • Dobson-Stone C, Polly P, Korgaonkar MS, Williams LM, Gordon E, Schofield PR, Mather K, Armstrong NJ, Wen W, Sachdev PS, Kwok JBJ, GSK3B and MAPT polymorphisms are associated with grey matter and intracranial volume in healthy individuals. PLoS ONE 2013; 8(8):e71750.
  • Strbenac D, Armstrong NJ, Yang JYH. Detection and classification of peaks in 5' cap RNA sequencing data. BMC Genomics 2013; 14(Supp 5):S9.
  • Parnell GP, Tang BM, Nalos M, Armstrong NJ, Huang SJ, Booth DR, McLean AS.Identifying key regulatory genes in the whole blood of septic patients to monitor underlying immune dysfunctions. Shock 2013; 40(3):166-174.
  • Suppiah V, Armstrong NJ, O'Connor KS, Berg T, Weltman M, Abate ML, Spengler U, Bassendine M, Dore GJ, Irving WL, Powell E, Nattermann J, Mueller T, Riordan S, Stewart GJ, George J, Booth DR, Ahlenstiel G; and the International Hepatitis C Genetics Consortium (IHCGC), Michalk M, Malik B, McClure P, Smith S, Sheridan D, Snape E, Fragomeli V, Norris R, How-Chow D, Jonsson JR, Barrie H, Stelzer-Braid S, Fletcher S, Applegate T, Grebely J, Matthews G, Bharadwaj M, Smedile A.CCR5-Δ32 genotype does not improve predictive value of IL28B polymorphisms for treatment response in chronic HCV infection. Genes and Immunity, 2013; 14(5):286-290.
  • Hulf T, Sibbritt T, Wiklund ED, Patterson K, Song JZ, Stirzaker C, Qu W, Nair S, Horvath LG, Armstrong NJ, Kench JG, Sutherland RL, Clark SJ. Epigenetic-induced repression of MicroRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer. Oncogene. 2013;32(23):2891-9
  • Kalyuga M, Gallego-Ortega D, Lee HJ, Roden D, Cowley MJ, Caldon CE, Stone A, Allerdice SL, Valdes-Mora F, Launchbury R, Statham A, Armstrong NJ, Alles C, Young A, Egger A, Au W, Piggin C, Evans C, Ledger A, Brummer T, Oakes SR, Kaplan W, Gee JMW, Nicholson RI, Sutherland RL, Swarbrick A, Naylor MJ, Clark S, Carroll JS, Ormandy CJ. ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. PLoS Biology. 2012;10(12):e1001461
  • Parnell GP, McLean AS, Booth DR, Armstrong NJ, Nalos M, Huang SJ, Manak J, Tang W, Tam OY, Chan S, Tang BM. A distinct influenza infection signature in the blood transcriptome of patients who presented with severe community acquired pneumonia. Critical Care. 2012;16(4):R157
  • Kirschner MB, Cheng YY, Badrian B, Kao SC, Creaney J, Edelman JJ, Armstrong NJ, Vallely MP, Musk AW, Robinson BWS, McCaughan BC, Klebe S, Mutsaers SE, van Zandwijk N, Reid G. Increased circulating miR-625-3p: a potential biomarker for patients with malignant pleural mesothelioma. J Thoracic Oncology. 2012;7(7):1184-91
  • Birzniece V, Meinhardt UJ, Gibney G, Johannsson G, Armstrong N, Baxter RC, Ho KKY. Differential effects of raloxifene and estrogen on body composition in growth hormone-replaced hypopituitary women. JCEM. 2012;97(3):1005-1012
  • Kirschner MB, Kao SC, Edelman JJ, Armstrong NJ, Vallely MP, van Zandwijk N, Reid G. Haemolysis during sample preparation alters microRNA content of plasma. PLoS One. 2011;6(9):e24145.
  • Kao SC, Armstrong NJ, Concon B, Griggs K, McCaughan B, Shepard S, Wilson A, Henderson DW, Klebe S. Aquaporin 1 is an independent prognostic factor in pleural malignant mesothelioma. Cancer. 2012;118(11):2952-61
  • Suppiah V, Gaudieri S, Armstrong NJ, O'Connor KS, Berg T, Weltman M, Abate ML, Spengler U, Bassendine M, Dore GJ, Irving WL, Powell E, Hellard M, Riordan S, Mathews G, Sheridan D, Nattermann J, Smedile A, Muller T, Hammond E, Dunn D, Negro F, Bochud P-Y, Mallal S, Ahlenstiel G, Stewart GJ, George J and Booth DR for the International Hepatitis C Genetics Consortium (IHCGC). IL28B, HLA-C and KIR variants additively and interactively predict response to therapy in chronic hepatitis C virus infection. PLoS Medicine. 2011;8(9):e1001092.
  • Kao SC, Klebe S, Henderson DW, Reid G, Chatfield M, Armstrong NJ, Yan T, Vardy J, Clarke S, van Zandwijk N, McCaughan B. Low Calretinin expression and high Neutrophil-to-Lymphocyte Ratio are poor prognostic factors in malignant mesothelioma patients undergoing extrapleural pneumonectomy. J Thoracic Oncology. 2011;6(11):1923-1929.
  • Kao SC, Griggs K, Lee K, Armstrong NJ, Clarke S, Vardy J, van Zandwijk N, Burn J, McCaughan BC, Henderson DW, Klebe S. Validation of the use of a minimal panel of antibodies for the diagnosis of malignant pleural mesothelioma. Pathology. 2011;43(2):128-132
  • Kao SC, Lee K, Armstrong NJ, Clarke S, Vardy J, van Zandwijk N, Reid G, Burn J, McCaughan BC, Henderson DW, Klebe S. Validation of tissue microarray technology in malignant pleural mesothelioma. Pathology. 2011;43(2):128-132.
  • Ghandi KS, McKay FC, Cox M, Riveros C, Armstrong NJ, Heard RN, Vucic S, Williams DW, Stankovich J, Brown M, Danoy P, Stewart GJ, Broadley S, Moscato P, Lechner-Scott J, Scott RJ, Booth DR, ANZgene Multiple Sclerosis Genetics Consoritum. The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Hum Mol Genet. 2010;19(11):2134-2143.
  • Gerlach C, van Heijst JWJ, Swart E, Sie D, Armstrong NJ, Kerkhoven RM, Zehn D, Bevan MJ, Schepers K, Schumacher TWM. One naive T cell, multiple fates in CD8+ T cell differentiation. J Exp Medicine. 2010;207(6):1235-1246.
  • Mook S, Schmidt MK, Rutgers EJ, van de Velde AO, Visser O, Rutgers SM, Armstrong NJ, van 't Veer LJ, Ravdin PM. Calibration and discriminatory accuracy of the web-based tool Adjuvant! in a hospital-based cohort of 5380 Dutch breast cancer patients. Lancet Oncology. 2009;10(11):1070-1076.,
  • Kreike B, Halfwerk H, Armstrong NJ, Bult P, Foekens JA, Veltkamp SC, Nuyten D, Bartelink H, van de Vijver MJ. Local recurrence after breast-conserving therapy in relation to gene expression patterns in a large series of patients. Clin Can Res. 2009;15(12):4181-4190.
  • Kok M, Koornstra RH, Margarido TC, Fles R, Armstrong NJ, Linn SC, van 't Veer LJ, Weigelt B. Mammosphere-derived gene set predicts outcome in patients with ER-positive breast cancer. J Pathology. 2009;218(3):316-326.
  • van den Broek GB, Wildeman M, Rasch CRN, Armstrong NJ, Schuuring E, Begg AC, Looijenga LHJ, Scheper R, van der Wal JE, Menkema L, van Diest PJ, Balm AJM, van Velthuysen MLF, van den Brekel MWM. Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation. Int J Cancer. 2009;124(11):2643-2650.
  • Reyal F, van Vliet MH, Armstrong NJ, Horlings HM, de Visser KE, Kok M, Teschendorff AE, Mook S, van't Veer L, Caldas C, Salmon RJ, van de Vijver MJ, Wessels LFA. A comprehensive analysis of prognostic signatures reveals the high predictive capacity of Proliferation, Immune response and RNA splicing modules in breast cancer. Breast Cancer Research. 2008;10(6):R93.
  • Armstrong NJ. The changing focus of microarray analysis. Statistica Neerlandica 2008;62(3):364-373.
  • Stam FJ, Macgillavry HD, Armstrong NJ, de Gunst MC, Zhang Y, van Kesteren RE, Smit AB, Verhaagen J. Identification of candidate transcriptional modulators involved in successful regeneration after nerve injury. European J Neuroscience. 2007;25(12):3629-3637.
  • Armstrong NJ, Brodnicki TC, Speed TP. Mind the gap: analysis of marker-assisted breeding strategies for inbred mouse strains. Mamm. Genome. 2006;17(4):273-287.
  • Armstrong NJ, McPeek MS, Speed TP. Incorporating interference into linkage analysis for experimental crosses. Biostatistics. 2006;7(3):374-386.
  • Rabbee N, Speca D, Armstrong NJ, Speed TP. Power calculations for selective genotyping in QTL mapping in backcross mice. Genet. Res.Camb. 2004;84:103-108.
  • Armstrong NJ, van de Wiel MA. Microarray data analysis: From hypotheses to conclusions using gene expression data. Cell Oncol. 2004;26(5-6):279-90.

Book Chapters
  • Zhou J, Belov L, Armstrong NJ, Christopherson RI. Antibody microarray and multiplexing. In Bioinformatics of Human Proteomics , Springer (2013).

  • Armstrong NJ, Incorporating Interference into the Linkage Analysis of Experimental Crosses , PhD thesis, University of California at Berkeley 2001.

last updated May 28, 2012