SMS scnews item created by Dario Strbenac at Tue 11 Feb 2020 1505
Type: Seminar
Modified: Thu 13 Feb 2020 2048
Distribution: World
Expiry: 21 Feb 2020
Calendar1: 17 Feb 2020 1300-1400
CalLoc1: AGR Carslaw 829
CalTitle1: Integrative Single Cell Omics Analysis of Breast Cancer
Auth: (dstr7320) in SMS-WASM

Statistical Bioinformatics Seminar: Trinh -- Integrative Single Cell Omics Analysis of Breast Cancer

The transition from early breast cancer (ductal carcinoma in situ: DCIS) to invasive
breast cancer (invasive ductal carcinoma: IDC) is an evolutionary bottleneck where
progression occurs only in 30% of patients. However, the molecular processes marking
this transition remain poorly understood. We profile the DCIS to IDC transition
from an integrated in situ and immunogenomics standpoint, using a combination of
exome sequencing, RNA-sequencing and cyclic immunofluorescence. I will discuss
how the tumor and immune system can collectively influence tumour evolution:
firstly, the role of immunosurveillance in shaping the evolutionary trajectory of
the tumour, and secondly, how genomic changes in tumour cells including oncogenic
hotspot mutations can contribute to immune escape.

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