SMS scnews item created by Dario Strbenac at Thu 22 Oct 2020 1500
Type: Seminar
Distribution: World
Expiry: 27 Oct 2020
Calendar1: 26 Oct 2020 1300-1330
CalLoc1: Zoom videoconferencing
Auth: dario@ (dstr7320) in SMS-WASM

Statistical Bioinformatics Webinar: Zanini -- The Art of Generating Hypotheses from Single Cell Data

Single cell transcriptomic data are being ammassed by many laboratories and are
revealing an amazing and sometimes overwhelming degree of heterogeneity within
organisms, tissues, and even within each individual cell type. The cell similarity graph
or network is a mathematical object at the core of such data sets, encoding phenotypic
heterogeneity in a simplified yet powerful form. I will give an overview of my lab
operations, centered around cell graphs and aimed at generating sound and interesting
hypotheses for biomedicine via data exploration and deep experimental collaborations.
I will present northstar, a new cell clustering/classification approach that is
particularly well suited for cancer and developmental biology. I will then discuss two
of our recent adventures in biomedicine: (1) constructing a cell atlas of the neonatal
lung and (2) understanding the corruption of hematopoietic gene regulatory networks
during acute myeloid leukemia.

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