SMS scnews item created by Dominic Tate at Sun 27 Aug 2017 2334
Type: Seminar
Distribution: World
Expiry: 27 Nov 2017
Calendar1: 28 Aug 2017 1700-1800
CalLoc1: Carslaw 535A
CalTitle1: MaPSS: Adrianne Jenner -- How does pressure within a tumour affect the outcome of cancer treatment?
Auth: dominict@14-200-3-233.static.tpgi.com.au (dtat6918) in SMS-WASM

# MaPSS: Mathematical Postgraduate Seminar Series: Jenner -- How does pressure within a tumour affect the outcome of cancer treatment?

Dear All,

We are delighted to present the MaPSS Seminar topic of Monday 28/08; please see the
abstract below.

**This Semester the Seminar will always run on Monday, at 5:00pm in 535A**

Following the talk, there will be pizza on offer.

Title: How does pressure within a tumour affect the outcome of cancer treatment?

Abstract: Pressure within tumour’s has been identified as one of the major culprits
impeding cancer treatments.  Tumour pressure is known to result in heterogeneous
intratumoural distribution of cancer treatments and increase the metastatic potential of
tumours.  We use a sytem of ODEs to initially optimise in vitro data.  We introduce
heterogeneous population characteristics into our model through the use of gamma
distributions.  From this we then build an off-lattice agent based model for the
interaction between tumour cells and a cancer treatment.  Investigations are undertaken
into the optimisation potential of pressure reducing treatments combined with alternate
treatment application profiles to discern how to enhance homogeneous treatment diffusion
without allowing the formation of metastasis.