Jonathan Arthur Sesqui Lecturer in Bioinformatics, Central Clinical School, Faculty of Medicine and SUBIT Identification of open reading frames in unannotated genome sequences Wednesday 24th August 14:05-14:55pm, Carslaw Building Room 373. Genome sequencing is now routine with genomic data for over 1000 organisms in GenBank. While important, the real value in genome sequencing comes from determining the location and nature of the genes within the genome and the proteins for which those genes code. Existing techniques for genome annotation have varying levels of accuracy and depend on various assumptions and hypotheses about the nature and location of open reading frames in the DNA sequence. This talk will describe an alternative, hypothesis independent method for annotating genome sequences using proteomic data.